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    Choon Low architect dead and obituary, cause of death – whats happened?

    Deregulation of translation initiation factor 4E (eIF4E) activity occurs in various types of cancer. Mitogen-activated protein kinase (MAPK)-interacting kinases 1 and 2 (MNK1 and MNK2) play important roles in the activation of eIF4E. Fragment hit expansion driven by structure-activity relationships led to the discovery of dual MNK1 and MNK2 inhibitors based on novel pyridine-benzamide scaffolds. These compounds showed promising in vitro and in vivo pharmacokinetic profiles and showed potent targeted inhibition of eIF4E phosphorylation in cells.

    The post Choon Low architect dead and obituary, cause of death – whats happened? appeared first on MRandom News.

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